The objectives of this study are to establish a collaboration for Japanese birth cohorts, led by The Japan Society for Developmental Origins of Health and Disease (J-DOHaD) and the DOHaD Seminar of Epidemiology, one of its subcommittees; to analyze the risk factors and prognosis of hypertensive disorders of pregnancy (HDP) and low birth weight (LBW) through individual and integrated analyses; and to develop methods for the prediction and early detection of perinatal and chronic diseases.

We will build a platform for collaboration among domestic birth cohort studies. This linkage platform will be updated and expanded as required. Concurrently, we will continue to explore analytical methods for conducting an integrated analysis of the associated risk factors and prognosis of HDP and LBW. Based on this, we will aim to create integrated risk prediction models for HDP and LBW using both individual analyses and an integrated meta-analysis.

Furthermore, to support the individual participant data (IPD) meta-analysis including information on the results of genome analysis, we will also collect information on actual cases in Japan and other countries and examine the feasibility of the IPD meta-analysis of genome birth cohorts in Japan. Finally, we will develop an application for integrated risk prediction based on the meta-analysis and aim for social implementation.